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. 2022 Jul 28;13(7):656. doi: 10.1038/s41419-022-05093-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A RGS6 mRNA expression in cancer tissues compared with the non-cancer counterparts from the LUAD and LUSC patients from TCGA. LUAD, lung adenocarcinoma; LUSC, lung squamous cell carcinoma (***p < 0.001). B qRT-PCR analysis of RGS6 mRNA levels in 92 human lung cancer tissues and paired noncancerous lung tissues. Mean values are indicted by solid bars, and values are expressed as mean ± SEM. T, tumor tissues; N, paired noncancerous lung tissues. C Relative expression of RGS6 mRNA in 92 paired lung cancer tissues. Y-axis represents the log2 transformed fold change of T/N expression ratios of RGS6 mRNA. The number of each specimen is shown below X-axis. D Relative expression (T/N) of RGS6 in non-metastatic (n = 44) and metastatic (n = 48) lung cancer tissues. Non-metastatic tissues were from lung cancer patients without any metastasis and metastatic tissues were from lung cancer patients with lymph node metastasis or distant metastasis (**p < 0.01). E RGS6 protein levels in lung cancer tissues and paired adjacent normal tissues were examined by IHC in tissues from 75 lung cancer patients. Left panel, representative IHC images. Right panel, RGS6 protein levels in tumor and normal tissues were quantified and shown as the IHC immunoreactivity score (IRS) (***p < 0.001). F Correlation between low RGS6 expression level and poor prognosis in lung cancer patients. LCA, lung carcinoma. Kaplan–Meier plots were generated using Kaplan–Meier Plotter (http://www.kmplot.com) (**p < 0.01). G RGS6 mRNA levels, H RGS6 protein levels in human lung epithelial cells (16-HBE) and six NSCLC cell lines (five adenocarcinoma cell lines: A549, SPC-A1, H1299, 95D and 95 C; as well as one squamous cell carcinoma cell line: H226). Each experiment was performed in triplicates (***p < 0.001).