Table 3.
AUC with 95% CI achieved by our models on the external CPTAC-3 test set for each somatic mutation. A model name followed by "-FT/FC" indicates the model is fine-tuned at the last fully-connected layer. A model name followed by "-FT/AL" indicates the model is fine-tuned at all of the layers (except batch-normalization layers). The AUC of 0.65 or higher is highlighted in bold.
| Models | BRAF | EGFR | KRAS | STK11 | TP53 |
|---|---|---|---|---|---|
| CNNLUAD-Feat-FT/FC | 0.456 | 0.605 | 0.598 | 0.527 | 0.475 |
| (0.270–0.638) | (0.530–0.680) | (0.519–0.677) | (0.428–0.625) | (0.392–0.558) | |
| CNNLUAD-Feat-FT/AL | 0.423 | 0.500 | 0.601 | 0.438 | 0.570 |
| (0.241–0.601) | (0.425–0.576) | (0.518–0.682) | (0.334–0.540) | (0.486–0.654) | |
| CNNImage-Feat-FT/FC | 0.550 | 0.513 | 0.457 | 0.478 | 0.400 |
| (0.411–0.690) | (0.462–0.563) | (0.378–0.535) | (0.373–0.581) | (0.324–0.476) | |
| CNNImage-Feat-FT/AL | `0.451 | 0.686 | 0.629 | 0.484 | 0.677 |
| (0.270–0.628) | (0.620–0.752) | (0.552–0.706) | (0.406–0.562) | (0.602–0.752) |