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. 2022 Jul 28;13:4374. doi: 10.1038/s41467-022-31442-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Representation of the methods used to evaluate Adcyap1, Adcyap1r1 regulation after FE1. b Adcyap1r1 mRNA regulation 30 min after FE1 in prefrontal cortex (PFC) (control: n = 6, IMO: n = 8), amygdala (AMY) (control: n = 10, IMO: n = 7) (P = 0.030), hypothalamus (HPT) (control: n = 10, IMO: n = 8) (P = 0.002), and periaqueductal gray (PAG) (control: n = 9, IMO: n = 9). c Adcyap1 in PFC (control: n = 6, IMO: n = 9), AMY (control: n = 11, IMO: n = 8), HPT (control: n = 11, IMO: n = 8) (P = 0.020), and PAG (control: n = 10, IMO: n = 8). Data are means ± SEM. *P ≤ 0.05, **P ≤ 0.01. Two-tailed t tests were conducted. IMO immobilization stress, FC fear conditioning, FE fear extinction. Source data are provided as a Source Data file.