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. 2022 Jul 28;13:4374. doi: 10.1038/s41467-022-31442-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Methods used for the assessment of the influence of rs2267735 genotype over FE (n = 71, 49). b Fear-potentiated startle magnitude of cycling women (≤40 years old) with CC or GC/GG genotypes during early FE and its relation to childhood trauma exposure (n = 71) (P = 0.030). Analyses for >40 years old (n = 49) are shown in Supplementary Fig. 9c. Data are means ± SEM. *P ≤ 0.05. Fear-potentiated startle data in b were analyzed with an ANCOVA with extinction as repeated measures variable, age, genotype, and childhood trauma as between-subjects variables. Covariates included GWAS principal components, total lifetime trauma, baseline startle. None of the CS+ presentations was paired with an US during the FE phase. CS+ reinforced conditioned stimulus, CS- non-reinforced conditioned stimulus, NA noise probe alone, US unconditioned stimulus. Source data are provided as a Source Data file.