Table 1.
Characteristics of teriparatide and alendronate group at baseline
| Teriparatide | Alendronate | P Value | |
|---|---|---|---|
| (n = 379) | (n = 194) | ||
| Age, year, mean ± SD | 64.20 ± 7.24 | 63.68 ± 6.96 | 0.415 |
| Nationality, n (%) | |||
| Han | 374 (98.68) | 190 (97.94) | 0.748 |
| Other | 5 (1.32) | 4 (2.06) | |
| Height (cm), mean ± SD | 155.10 ± 6.24 | 154.86 ± 5.81 | 0.660 |
| Body weight (kg), mean ± SD | 55.58 ± 7.29 | 55.14 ± 7.35 | 0.488 |
| Time since menopause (year), mean ± SD | 15.67 ± 7.90 | 14.83 ± 7.54 | 0.234 |
| Comorbidities, n (%) | 215 (56.88) | 97 (50.00) | 0.132 |
| Hypertension | 102 (26.91) | 48 (24.74) | 0.576 |
| Dyslipidemia | 54 (14.25) | 22 (11.34) | 0.331 |
| Diabetes | 30 (7.92) | 11 (5.67) | 0.324 |
| Osteoarthritis | 10 (2.64) | 3 (1.55) | 0.558 |
| Others | 158 (41.69) | 70 (36.08) | 0.194 |
| Concomitant medications, n (%) | 171 (45.24) | 87(44.85) | 1.000 |
| Chinese patent medicine | 132 (34.8) | 60 (30.9) | 0.197 |
| Antipyretic analgesics | 42 (11.08) | 25 (12.89) | 0.583 |
| Anxiolytics | 14 (3.69) | 4 (2.06) | 0.448 |
| Antihypertensive drugs | 14 (3.69) | 6 (3.09) | 0.711 |
| Previous history of fracture, n (%) | 130 (34.30) | 74 (38.14) | 0.363 |
| Vertebral fracture | 65 (17.15) | 37 (19.07) | 0.569 |
| Colles fracture | 31 (8.18) | 18 (9.28) | 0.656 |
| Hip fracture | 11 (2.90) | 6 (3.09) | 0.899 |
| Other fracture | 58 (15.30) | 25 (12.89) | 0.437 |
| BMD, mean ± SD | |||
| Lumbar (L1-4) (g/cm2) | 0.736 ± 0.103 | 0.741 ± 0.098 | 0.550 |
| Total hip (g/cm2) | 0.709 ± 0.094 | 0.711 ± 0.096 | 0.818 |
| P1NP (ng/ml) | 56.36(38.16–74.87) | 57.69(37.56–79.59) | 0.225 |
| β-CTX (ng/ml) | 0.36(0.24–0.49) | 0.35(0.22–0.51) | 0.837 |
| Ca (mmol/L) | 2.35 ± 0.10 | 2.35 ± 0.11 | 0.986 |
| P (mmol/L) | 1.16 ± 0.14 | 1.16 ± 0.20 | 0.870 |
| ALP (U/L) | 79.37 ± 22.35 | 82.67 ± 22.25 | 0.094 |
| Cr (μmol/L) | 59.91 ± 10.08 | 58.61 ± 10.46 | 0.170 |
| ALT (U/L) | 19.68 ± 9.96 | 20.72 ± 10.06 | 0.247 |
PTH parathyroid hormone, n number, SD standard deviation, P1NP procollagen type 1 N-terminal propeptide, β-CTX β-C-terminal telopeptide of type 1 collagen, S-Ca serum calcium, S-P serum phosphorus, ALP alkaline phosphatase, Cr creatinine, ALT alanine aminotransferase