Atopic dermatitis (AD) has a multitude of symptoms that affect patients beyond the efficacy endpoints used by regulatory authorities when evaluating treatment success. To fully understand the ability of treatments to control disease, other endpoints and timepoints need to be considered.

To provide a better understanding of the impact of tralokinumab over time on multiple disease domains, we assessed the timing, magnitude, and sustainability of the effect over the entire 32-week treatment period of the ECZTRA 3 trial, including all patients initiated on tralokinumab irrespective of the response achieved at Week 16. Tralokinumab plus topical corticosteroids provided progressive and sustained improvements in both clinician- and patient-reported outcomes, including AD signs, symptoms, and health-related quality of life over 32 weeks.

These results provide a more complete overview of the benefits of tralokinumab over time, which may help inform clinical decisions.