Table 2.
Infection characteristics in patients with IFIs during the study (FAS)
| Isavuconazole (n = 510) | Posaconazole (n = 540) | Voriconazole (n = 491) | Multiple/sequenced MAT therapies (n = 452) | Total (N = 1993) | |
|---|---|---|---|---|---|
| Patients with IFIsa | 61 (12.0) | 43 (8.0) | 49 (10.0) | 133 (29.4) | 286 (14.4) |
| Highest level of IFI diagnosis, na | 58 | 40 | 41 | 123 | 262 |
| Proven | 26 (44.8) | 23 (57.5) | 15 (36.6) | 65 (52.8) | 129 (49.2) |
| Probable | 21 (36.2) | 12 (30.0) | 18 (43.9) | 29 (23.6) | 80 (30.5) |
| Possible | 11 (19.0) | 5 (12.5) | 8 (19.5) | 29 (23.6) | 53 (20.2) |
| Pathogen treated, nab | 55 | 43 | 47 | 123 | 268 |
| Genus species | |||||
| Aspergillus | 24 (43.6) | 9 (20.9) | 23 (48.9) | 53 (43.1) | 109 (40.7) |
| fumigatus | 10 (18.2) | 6 (14.0) | 12 (25.5) | 14 (11.4) | 42 (15.7) |
| niger | 1 (1.8) | 1 (2.3) | 2 (4.3) | 9 (7.3) | 13 (4.9) |
| flavus | 1 (1.8) | 0 | 1 (2.1) | 2 (1.6) | 4 (1.5) |
| versicolor | 0 | 0 | 3 (6.4) | 0 | 3 (1.1) |
| Not specified | 9 (16.4) | 2 (4.7) | 5 (10.6) | 23 (18.7) | 39 (14.6) |
| Candida | 17 (30.9) | 14 (32.6) | 12 (25.5) | 22 (17.9) | 65 (24.3) |
| glabrata | 8 (14.5) | 9 (20.9) | 4 (8.5) | 6 (4.9) | 27 (10.1) |
| krusei | 4 (7.3) | 1 (2.3) | 0 | 2 (1.6) | 7 (2.6) |
| parapsilosis | 3 (5.5) | 2 (4.7) | 0 | 1 (0.8) | 6 (2.2) |
| albicans | 2 (3.6) | 5 (11.6) | 7 (14.9) | 8 (6.5) | 22 (8.2) |
| dubliniensis | 1 (1.8) | 0 | 1 (2.1) | 3 (2.4) | 5 (1.9) |
| tropicalis | 1 (1.8) | 0 | 1 (2.1) | 2 (1.6) | 4 (1.5) |
| Not specified | 1 (1.8) | 1 (2.3) | 0 | 4 (3.3) | 6 (2.2) |
| Rhizopus | 3 (5.5) | 1 (2.3) | 0 | 7 (5.7) | 11 (4.1) |
| Mucor | 2 (3.6) | 0 | 1 (2.1) | 6 (4.9) | 9 (3.4) |
| Penicillium | 1 (1.8) | 1 (2.3) | 1 (2.1) | 3 (2.4) | 6 (2.2) |
| Coccidioides | 1 (1.8) | 9 (20.9) | 0 | 3 (2.4) | 13 (4.9) |
| Histoplasma | 1 (1.8) | 0 | 4 (8.5) | 5 (4.1) | 10 (3.7) |
| capsulatum | 1 (1.8) | 0 | 4 (8.5) | 3 (2.4) | 8 (3.0) |
| Scedosporium | 1 (1.8) | 0 | 0 | 3 (2.4) | 4 (1.5) |
| Fusarium | 0 | 2 (4.7) | 1 (2.1) | 7 (5.7) | 10 (3.7) |
| Other | 7 (12.7) | 7 (16.3) | 6 (12.8) | 19 (15.4) | 39 (14.6) |
Data are n (%), unless otherwise indicated
FAS full analysis set, IFI invasive fungal infection
aThe number of patients (n) with at least one IFI during the study and non-missing data for that parameter
bOnly incidences of ≥ 1% are shown