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. 2022 Jul 15;9:931759. doi: 10.3389/fmolb.2022.931759

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Copyright © 2022 Yang, Yang, Lu, Gong, Yang, Lin, Li and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Nanotechnology-based strategies for treatment and diagnosis of ocular disease. (A) Drug delivery; The main nanoparticles currently being investigated for drug delivery in ophthalmology are nano-polymer, liposomes, nanoemulsion, nanomicelles, quantum dots, (mesoporous) silica nanoparticles (SiNPs/MSiNPs), gold nanoparticles (AuNPs) and carbon nanotubes. (B) Nanoparticles application in ocular diseases. B-1 Carriers for drugs: There are currently three routes of drug delivery by nanocarriers, mainly eye drops, intravitreal injection, subconjunctival injection, and systemic administration. B-2 Auxiliary diagnosis includes nanoparticles as a contrast agent to enhance the resolution of ophthalmic OCT and PAM examinations, nanoparticles fused to cells can tracer transplanted cells in cell transplantation therapy, and nanoparticles allow real-time detection of intracellular dopamine levels.