TABLE 3.
The anticancer activities of the title compounds 5a−5w at 5 μg/ml.
Compound | Mortality rate (%) | |||
---|---|---|---|---|
PC3 | K562 | Hela | A549 | |
5a | 0 | 10.03 ± 1.03 | 3.82 ± 2.64 | 15.76 ± 1.30 |
5b | 15.53 ± 1.08 | 0 | 2.42 ± 1.06 | 13.65 ± 2.43 |
5c | 0 | 19.59 ± 1.30 | 5.98 ± 1.09 | 13.74 ± 1.76 |
5d | 5.80 ± 2.13 | 4.73 ± 2.15 | 11.37 ± 2.15 | 13.60 ± 2.80 |
5e | 0 | 5.30 ± 1.16 | 0.55 ± 2.24 | 9.23 ± 1.32 |
5f | 4.08 ± 1.67 | 21.88 ± 2.24 | 4.23 ± 1.25 | 12.47 ± 2.35 |
5g | 0 | 15.52 ± 1.61 | 2.75 ± 1.60 | 14.51 ± 2.35 |
5h | 0 | 10.98 ± 1.14 | 0 | 0.22 ± 1.05 |
5i | 3.98 ± 1.22 | 3.53 ± 1.95 | 3.58 ± 1.69 | 15.15 ± 2.64 |
5j | 31.01 ± 1.90 | 30.99 ± 2.06 | 25.22 ± 2.37 | 22.75 ± 2.94 |
5k | 34.20 ± 2.01 | 37.80 ± 1.95 | 34.50 ± 1.89 | 28.50 ± 2.22 |
5l | 54.94 ± 1.51 | 15.47 ± 1.38 | 32.20 ± 2.10 | 37.35 ± 2.00 |
5m | 0 | 0 | 0 | 0 |
5n | 51.71 ± 1.20 | 17.11 ± 1.52 | 30.78 ± 1.45 | 40.78 ± 1.09 |
5o | 50.52 ± 1.22 | 19.40 ± 1.64 | 39.54 ± 2.22 | 38.78 ± 2.26 |
5p | 9.20 ± 1.45 | 7.30 ± 2.01 | 20.40 ± 1.70 | 16.80 ± 3.26 |
5q | 46.11 ± 1.54 | 31.40 ± 3.12 | 37.90 ± 3.01 | 42.42 ± 1.33 |
5r | 55.32 ± 1.35 | 15.63 ± 0.96 | 34.65 ± 1.87 | 41.36 ± 1.51 |
5s | 22.35 ± 1.16 | 5.28 ± 1.38 | 25.14 ± 2.03 | 15.24 ± 1.67 |
5t | 0.37 ± 1.23 | 12.46 ± 2.26 | 6.87 ± 2.07 | 8.41 ± 2.83 |
5u | 31.01 ± 1.64 | 30.99 ± 1.34 | 25.22 ± 2.35 | 22.75 ± 2.90 |
5v | 64.20 ± 1.12 | 24.00 ± 1.92 | 48.25 ± 1.17 | 34.20 ± 2.31 |
5w | 36.20 ± 1.36 | 35.40 ± 1.83 | 32.20 ± 2.62 | 31.80 ± 2.08 |
Doxorubicin | 94.68 ± 1.05 | 72.81 ± 1.54 | 80.43 ± 1.36 | 89.57 ± 2.07 |