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. 2022 Jul 28;8:339. doi: 10.1038/s41420-022-01132-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A–C The siRNA-KDM6B inhibited the increased mRNA and protein expression level of migration-related genes promoted by TGF-β1. D, E The IF showed the CXCR4 expression in presence of TGF-β1 upon siRNA-KDM6B. F, G The siRNA-KDM6B significantly inhibited the actin cortical protrusions formation promoted by TGF-β1. H, I The scratch test showed that siRNA-KDM6B decreased the migration area of BMSCs, and also inhibited the migration area promoted by TGF-β1. J, K Transwell test verified that siRNA-KDM6B inhibited the migrated MSCs number promoted by TGF-β1. (^*P < 0.05, ^**P < 0.01, ^***P < 0.001 in comparison with the control group; ^##P < 0.01, ^###P < 0.001 in comparison with TGF-β1 group. All experiments were repeated three times independently. All error bars ± standard deviation.).