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. 2022 Jul 28;12:12921. doi: 10.1038/s41598-022-17081-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Subclustering reveals potential functions of OPCs. (A) Subclustering of OPC1 into 3 subclusters (OPC1a, OPC1b, and OPC1c). (B) Violin plots depicting expression of genes related to metabolism that are significantly upregulated in OPC1a and genes related to the extracellular matrix that are significantly upregulated in OPC1c. Each dot represents a cell. (C) Subclustering of OPC2 into 2 subclusters (OPC2a and OPC2b). (D) Violin plots depicting expression of genes related to neuronal regulation that are significantly upregulated in OPC2a and genes related to the cell cycle that are significantly upregulated in OPC2b. Each dot represents a cell.