Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jul 28;5:756. doi: 10.1038/s42003-022-03702-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — TOPMed features of distinct, significant and suggestive signals associated with fasting glucose and fasting insulin (log-transformed) in pooled analysis. P-values (unconditional −log10-transformed) for glycemic and related traits (HbAa1c and type 2 diabetes) and effect allele frequency (with respect to the pooled analysis effect allele) across race/ethnicities in TOPMed are reported. Chromatin states at relevant tissues were drawn from two sets of experiments from DGA^46,47; annotation PCs provide summaries of multi-faceted variant function; variants that are significant eQTLs in relevant tissues are denoted. EAF, effect allele frequency for TOPMed sample; EnhA1, Active Enhancer 1; EnhA2, Active Enhancer 2; Het, Heterochromatin; Quies, Quiescent/Low; ReprPC, Repressed PolyComb; ReprPCWk, Weak Repressed PolyComb; TssA, Active TSS; TssFlnk, Flanking TSS; TxWk, Weak Transcription; ZNF/Rpts, ZNF genes & repeats.