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. 2022 Jul 15;10:888636. doi: 10.3389/fchem.2022.888636

TABLE 1.

Instrumental conditions of Thermo Fisher iCAP TQ ICP-MS/MS for impurity analysis.

ICP source operation parameters
RF power 1550 W
Ar plasma gas flow 16 L/min
Ar auxiliary gas flow 1.0 L/min
Nebulizer gas flow 1.12 L/min
Nebulizer Borosilicate glass concentric nebulizer
Sample uptake rate 0.3 ml min−1
Spray chamber Borosilicate glass cyclonic spray chamber
Sampling cone and skimmer cone Ni sampling cone, Ni skimmer cone
Spectrometer operating parameters
Measured isotopes and measurement modes Single Quadrupole Mass Spectrometry mode
89Y, 141Pr, 142Ce, 143Nd, 145Nd, 146Nd, 147Sm, 149Sm, 151Eu, 157Gd, 159Tb, 161Dy, 163Dy, 165Ho, 166Er, 167Er, 169Tm, 172Yb, 175Lu, 232Th
H2 gas collision reaction mode; H2 gas flow 10 ml min−1
45Sc (45; m/z at QMS1, 45: m/z at QMS2)
Dwell time 100 ms
Number of sweeps Ten times
Measurement repetition Five times