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. 2022 Jul 15;16:922181. doi: 10.3389/fncel.2022.922181

FIGURE 2.

FIGURE 2

Vascular morphology. Microvascular proliferations at the invasive edge of GBM—(A) glomeruloid vascular proliferation (white arrow) and vascular garlands (black arrows). (B) CD31 expression in a vascular garland seen by immunohistochemistry. (C) Metastasis of clear cell renal cell carcinoma to the brain seen on the right side surrounded by microvascular proliferation (arrow). (D) Pulmonary non-mucinous adenocarcinoma metastatic to the brain (bottom left corner) surrounded by multiple glomeruloid microvascular proliferations (arrows). (E) Perivascular infiltration of the PCNSL intermingled with reactive lymphocytes forming vascular cuffs. (F) Reticulin-specific stain highlights the complex reticulin web encompassing the tumor cell caused by neoplastic lymphoid cells penetrating through the vascular wall. (G) Vessels in acute abscess in the brain with leukostasis and neutrophil transmigration across the BBB. H, vessels in chronic abscess display reactive pericytes prominently (white arrows), and no microvascular proliferations are seen. Panels (A–D) magnification 100x, panels (E–H) magnification 400x.