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. 2022 Jul 15;12:898125. doi: 10.3389/fcimb.2022.898125

Figure 2.

Figure 2

Substitutions in PhoPQ and PmrAB are unevenly scattered across the proteins. Schematic diagram representing the domain structure of PhoPQ and PmrAB according to InterPro. Amino acid positions are indicated for each domain and for the full length protein. Phosphorylated amino acids are shown as red dots: H277 and H153 in PhoQ and PmrB, respectively, and D51 in PhoP and PmrA. Black dots represent amino acid substitutions encoded in isolates carrying intact mgrB. Three isolates carry several mutations in PmrAB and PhoQ, which are shown solely as dots and are not explored further (CBB22114: PmrA S64A, N131D, L140Q, E199D; PmrB N105S, A228T, Q232E, I242V, N244S, T246A; PhoQ A69K, Q92K, A106T, E112D, I139V, L163F, V196I, Q424P. CBB22871: PmrB N105S, A228T, Q232E, I242V, N244S, T246A, E272Q; PhoQ L163F, V196I, A325V; CBB23286: PmrB N105S, A228T, Q232E, I242V, N244S, T246A, E272Q; PhoQ R64K, Q92K, A106T, E112D, I139V, L163F, V196I, T372S, Q424P).