Table 2.
Nanoparticles based numerous biopolymeric compounds and their action in various cancer treatments.
| S. No. | Biopolymeric nanoparticles | Size (nm) | Polymer component | Actions | Bioactive molecules | Effects | Applications | References |
| 1. | Andrographolide analog chitosan based NPs | 112–240 | Octyl-grafted succinyl chitosan, naphthyl-grafted succinyl chitosan, and benzyl-grafted succinyl chitosan | Delivering anticancer medications to the sites of colon cancer | Andrographolide analog | Induces apoptosis | Colon cancer | (65) |
| 2. | DOX-verapamil/MPEG-PLA NPs | 25 | MPEG-PLA | Co-delivery system –efficiently chemotherapeutic agents and coencapsulate verapamil | Doxorubicin, Verapamil | Tumor suppression | Ovarian cancer | (66) |
| 3. | Linoleic acid conjugated SN38-loaded NPs | 109 | PEO-PBO diblock copolymer | – | Linoleic acid conjugated SN38 | EBNPs inhibit growth and promote uptake in cancer cells | Colorectal cancer | (67) |
| 4. | Curcumin- loaded Polymeric poly NPs | 200 | PLGA | Increased serum stability over free curcumin | Curcumin | Irradiating tumor cells at a low dose produces cytotoxic effects that inhibit tumor growth | Ovarian cancer | (68) |
| 5. | Epidermal growth factor receptor-targeted lipid polymeric NPs | 141.6 | EGF-PEG-DSPE | Targeting the drug delivery | Cisplatin and Doxorubicin | Enhanced cytotoxicity with anticancer activity | Lung cancer | (69) |
| 6. | Chondroitin sulfate functionalized campththecin-loaded polymeric NPs | 289 | Chitosan | Targeted drug delivery | Campththecin | Promote apoptosis | Colon cancer | (70) |
| 7. | Albendazole-loaded polyurethane NPs | 128.1 | Polyurethane | Better medication delivery | Albendazole | Increase the anticancer efficacy via inducing apoptosis | Breast cancer | (71) |
| 8. | Bortezomib loaded polymeric NPs | 199.7 | HPLA-BT | Higher drug load and its delivery | Bortezomib | Significant anticancer activity and shows higher cytotoxic effects | Breast cancer | (72) |
| 9. | Gemcitabine NPs conjugated with linoleic acid. | ~ 150 | Linoleic acid | High drug-load, improved intracellular uptake and controlled release | Gemcitabine | Induce apoptosis and improve cytotoxic activity | Thyroid cancer | (73) |
| 11. | Platinum–curcumin complexes loaded into pH and redox dual-responsive NPs | ~ 100 | mPEG-SS-PBAE-PLGA | Synergistic anticancer effects and control intracellular release | Platinum–curcumin | Improved anti-metastatic activity and synergistic anticancer implications | Lung cancer | (74) |
| 12. | Uncariatomentosa extract -PLGA & UTPCL | 300 | PCL and PLGA | Better drug delivery | Uncariatomentosa extract | – | Prostate cancer | (75) |
DOX, Doxorubicin; PBA, Phenylboronic acid; PLA, Polylactic Acid; PLGA, Polylactide-co-glycolide; HPLA-BT, N-(2- hydroxypropyl) methacrylamide (HPMA)-PLA-Biotin; MPEG-PLA, Methoxy poly(ethylene glycol)- poly(lactide) copolymer; PEO-PBO, poly (ethylene oxide)-poly (butylene oxide) DSPE-PEG, 1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine- polyethylene glycol; PBAE, Poly-beta-amino ester.