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. 2022 Jul 29;5:764. doi: 10.1038/s42003-022-03722-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b The relationship between connectivity and cluster coefficients at ZT06 and ZT18. c, d Gene clustering dendrogram and module distributions at ZT06 and ZT18, of which 43 and 42 modules were assigned, respectively. e The proportion of global cycling genes and non-cycling genes of all differentially connected genes. f Euclidean distance between global cycling genes and non-cycling genes within the networks. g Significance of the disease modules at ZT06 and ZT18. h The network-based distance of representative disease modules at ZT06 and ZT18 and the statistical significance of the difference. i Top 10 enriched biological pathways of genes with less connectivity at ZT06. j Top 10 enriched biological pathways for genes with less connectivity at ZT18.