Figure 5.

Pyroptosis-inducing therapies enhance the efficacy of ICB therapy. Pyroptotic cancer cells may promote T cell maturation and migration, and anti-tumor effects by releasing DAMPs, tumor antigens, and cytokines. Increasing numbers of CD8⁺ T cells lay the groundwork for ICIs. Furthermore, the granzyme released by CD8⁺ T cells increases tumor pyroptosis, thus creating a positive feedback loop for tumor immunotherapy. Overall, combining localized pyroptosis-inducing therapy and ICB may potentially augment the therapeutic efficacy of immunotherapy.