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. 2021 Aug 17;19(7):1029–1046. doi: 10.20892/j.issn.2095-3941.2020.0516

Table 1.

Univariate and multivariate Cox regression analyses for survival, using the TIMER database

Variables Univariate analysis
Multivariate analysis
HR 95% CI P-value HR 95% CI P-value
Age 1.028 1.007–1.049 0.010* 1.031 1.009–1.053 0.006*
Gender, male 0.813 0.541–1.222 0.319
Race
 Black 1.210 0.324–4.519 0.777
 White 1.264 0.511–3.127 0.613
Stage
 2 2.350 1.078–5.125 0.032*
 3 1.055 0.129–8.643 0.960
 4 1.594 0.327–7.780 0.564
Tumor purity 0.454 0.214–0.963 0.040* 0.687 0.288–1.637 0.396
B cells 1.664 0.112–24.800 0.712
CD8+ T cells 18.719 1.056–331.683 0.046* 6.825 0.184–253.697 0.298
CD4+ T cells 0.010 0.000–1.822 0.083
Macrophages 0.861 0.026–28.261 0.933
Neutrophils 476.588 0.286–795522.500 0.103
Dendritic cells 2.292 0.444–11.841 0.322
ANLN 1.573 1.297–1.908 < 0.001* 1.323 0.879–1.991 0.179
ASPM 1.749 1.322–2.312 < 0.001* 0.670 0.366–1.228 0.195
CDK1 1.746 1.354–2.252 < 0.001* 1.041 0.514–2.108 0.912
CEP55 1.765 1.387–2.246 < 0.001* 1.626 0.812–3.253 0.170
DLGAP5 1.745 1.367–2.227 < 0.001* 0.594 0.359–0.983 0.043*
NUSAP1 1.769 1.358–2.305 < 0.001* 1.061 0.550–2.044 0.861

References included: female for gender, white for race, and stage 1 for tumor stage. *P < 0.05 was considered statistically significant. TIMER, Tumor Immune Estimation Resource; HR, hazard ratio; CI, confidence interval.

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