Table 1.
Basic characteristics, intervention measures, follow-up time, and outcome indicators of the included literatures.
| Author | Year of publication | Women age (years) | BMI (kg/m2) | Population (E/C) | Intervention group | Control group | Outcome indicators |
|---|---|---|---|---|---|---|---|
| Picón-César MJ et al. (10) | 2021 | 34.86 ± 4.83 | 30.42 ± 5.42 | 100/100 | Metformina Sandoz 850 mg/d, maximum 2,550 mg/d | Insulin 0.1 IU/kg/meal | (a) (b) (c) (d) (e) (f) |
| Kulshrestha V et al. (11) | 2021 | 29.7 ± 4.4 | 25.5 ± 4.0 | 49/50 | Metformin 1,000 mg twice daily | Insulin 0.1 IU/kg/meal | (d) (f) |
| Feig DS et al. (12) | 2016 | 34.7 ± 5.0 | 35.0 ± 7.1 | 253/249 | Metformin 1,000 mg twice daily | Insulin 0.1 IU/kg/meal | (c) (e) (f) |
| Casey BM et al. (13) | 2015 | 31.3 ± 6 | 29.0 ± 4.8 | 189/186 | Glyburide maximum of 20 mg per day | Insulin 0.1 IU/kg/meal | (d) (e) (f) |
| Beyuo T et al. (14) | 2015 | 33.51 ± 4.67 | 33.47 ± 6.95 | 113/117 | Metformin start dose 500 mg/d, max 2,500 mg/d | Insulin 0.1 IU/kg/meal | (a) (b) |
| Ainuddin J et al. (15) | 2015 | 30.6 ± 2.9 | N/A | 43/75 | Metformin start dose 500 mg/d, max 2,500 mg/d | Insulin 0.1 IU/kg/meal | (a) (b) (c) (d) (e) |
| Mirzamı M et al. (16) | 2015 | 29.50 ± 4.06 | N/A | 37/59 | 1.25 mg glyburide with morning meal | Insulin 0.4 unit/kg | (a) (b) |
| Spaulonci CP et al. (17) | 2013 | 31.93 ± 6.02 | 31.96 ± 4.75 | 47/47 | Initial metformin dose of 1,700 mg/d (850 mg three times a day) | Insulin 0.4 unit/kg | (a) (b) |
| Tempe A et al. (18) | 2013 | N/A | N/A | 32/32 | Glyburide 2.5 mg orally as the initial dose | Insulin 0.4 unit/kg | (e) (f) |
| Niromanesh S et al. (19) | 2012 | 30.7 ± 5.5 | 28.1 ± 4.0 | 80/80 | initial metformin dose of 500 mg | Insulin 0.7 U/kg/d | (a) (b) (c) (d) (f) |
Abbreviation: E indicates the intervention group and C indicates the control group.
Outcomes: (a) Fasting blood glucose; (b) Postprandial glycemia after lunch; (c) HbA1c; (d) Maternal weight gain; (e) Abortion rate; (f) Cesarean section rate.