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. 2022 Jul 15;9:938677. doi: 10.3389/fmolb.2022.938677

FIGURE 2.

FIGURE 2

P53 potentiates ferroptosis through nine pathways and attenuates ferroptosis through three pathways. P53 promotes ferroptosis at high levels of oxidative stress. Ferroptosis is promoted by P53 inhibition of SLC7A11 expression. The consequent inhibition of cystine uptake and the release of ALOX12 contribute to ferroptosis. P53 inhibits tumor cell growth by promoting SAT1-ALOX15 and GLS-glutaminolysis axes, respectively. P53 inhibits GSH synthesis through PHGDH. P53 also promotes ferroptosis by enhancing the expression of LncRNA PVT1, SLC25A28, PTGS2 and CBS. Nevertheless, P53 inhibits ferroptosis at basal or low levels of oxygen radical pressure. P53 inhibits ferroptosis by raising the expression of iPLA2β and CDKN1A. P53 protects cells from ferroptosis by inhibiting DPP4 binding to NOX1.