Table 2.

Comparison of assessment and evaluation items used for centralized and decentralized research groups

Assessment and evaluation item		Centralized research group	Decentralized research group
Demographic information		Case report form and S.Y.M. app platform - required	S.Y.M. app platform - optional
		Gender, age, height, weight, socio-economic status, average annual household income, education level, occupation, marital status (number of children), religion, menopause (for women only)	Gender, age, height, weight, average annual household income, education level, occupation, marital status (number of children), religion, menopause (for women only)
Clinical information		Case report form and S.Y.M. app platform - required	S.Y.M. app platform - optional
		Past medical and psychiatric history, current medication history, previous suicide attempt history, current suicidal ideation and attempt, family history, smoking, alcohol drinking	Past medical and psychiatric history, current medication history, previous suicide attempt history, current suicidal ideation and attempt, family history
Blood sample collection		Venous blood 10 mL	-
Objective assessment (by clinical investigator)		MINI, ALDA, MADRS, YMRS, CGI-BP, HAM-A	-
Subjective assessment (self-rating)		S.Y.M. app platform - required	S.Y.M. app platform - optional
		PHQ-9, STAI-X1 and X2, GAD-7, APPQ, CES-D, ACQ, BSQ, KOSS-SF, SSI, AUDIT, HSI, DAST, ILQ, SLQ, CSM, SPAQ, BRIAN, LES, IPAQ-SF, MDQ, KRQ-53, WHOQOL-BREF, SWBS, KSS, TAS-20K, BFNE, SADS, DAI-10, CTQ
S.Y.M. app platform
	Daily Lifelog	Alcohol, caffeine, smoking, meal, exercise, menstruation (for women only)
	Daily Mood Log	Panic symptoms (onset time, duration, intensity, detailed symptom type)
		Affective states (mood, energy, anxiety, irritation) scoring
	Mood Calendar	Today’s mood (emoticon), stories about today (freewriting)
Wearable device		Fitbit wearables - required	Fitbit or Xiaomi wearables - optional
		Heart rate, activity, sleep	Heart rate, activity, sleep

S.Y.M. app, Search Your Mind application; MINI, Mini International Neuropsychiatric Interview; ALDA, ALDA questionnaire for Lithium treatment response; MADRS, Montgomery Åsberg Depression Scale; YMRS, Young Mania Rating Scale; HAM-A, Hamilton Anxiety Rating Scale; CGI-BP, Clinical Global Impression-Bipolar; PHQ-9, Patient Health Questionnaire-9; STAI, State-Trait Anxiety Inventory; GAD-7, Generalized Anxiety Disorder Scale-7; APPQ, Albany Panic and Phobia Questionnaire; CES-D, Center for Epidemiological Studies–Depression Scale; ACQ, Agoraphobic Cognition Questionnaire; BSQ, Body Sensation Questionnaire; KOSS-SF, The Short Form of Korean Occupational Stress Scale; SSI, Beck’s Scale for Suicidal Ideation; AUDIT, Alcohol Use Disorders Identification Test; HSI, Heavy Smoking Index; DAST, Drug Abuse Screening Test; ILQ, Internet Lifestyle Questionnaire; SLQ, Smartphone Lifestyle Questionnaire; CSM, Composite Scale of Morningness; SPAQ, Seasonal Pattern Assessment Questionnaire; BRIAN, Biological Rhythms Interview of Assessment in Neuropsychiatry; LES, Life Experiences Survey; IPAQ-SF, International Physical Activity Questionnaire–Short Form; MDQ, Mood Disorder Questionnaire; KRQ-53, Korean Resilience Quotient-53; WHOQOL-BREF, World Health Organization Quality of Life Scale abbreviated version; SWBS, Spiritual Well-Being Scale; KSS, Korean Spirituality Scale; TAS-20K, Korean version of the 20-item Toronto Alexithymia Scale; BFNE, Brief-Fear of Negative Evaluation Scale; SADS, Social Avoidance and Distress Scale; DAI-10, Drug Attitude Inventory-10; CTQ, Childhood Trauma Questionnaire