Table 2.
Correlation between striatal dopamine synthesis (Kicer) and frontostriatal connectivity (FA)
FA | Left AST |
Right AST |
Left LST |
Right LST |
||||
---|---|---|---|---|---|---|---|---|
r | p | r | p | r | p | r | p | |
Healthy controls | ||||||||
Left DLPFC-AST | -0.277 | 0.384 | ||||||
Right DLPFC-AST | -0.19 | 0.553 | ||||||
Left VMPFC-LST | 0.077 | 0.812 | ||||||
Right VMPFC-LST | 0.231 | 0.471 | ||||||
Treatment-responsive schizophrenia | ||||||||
Left DLPFC-AST | -0.629* | 0.028 | ||||||
Right DLPFC-AST | -0.21 | 0.513 | ||||||
Left VMPFC-LST | 0.112 | 0.729 | ||||||
Right VMPFC-LST | 0.329 | 0.297 | ||||||
Treatment-resistant schizophrenia | ||||||||
Left DLPFC-AST | -0.07 | 0.829 | ||||||
Right DLPFC-AST | -0.182 | 0.572 | ||||||
Left VMPFC-LST | -0.049 | 0.88 | ||||||
Right VMPFC-LST | 0.427 | 0.167 |
correlation is significant at the 0.05 level (2-tailed).
FA, fractional anisotropy; Kicer, influx constant; DLPFC-AST, dorsolateral prefrontal cortex-associative striatum; VMPFC-LST, ventromedial prefrontal cortex-limbic striatum; AST, associative striatum; LST, limbic striatum; r, correlation coefficient; p, significant level