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. 2022 Jul 15;13:907481. doi: 10.3389/fimmu.2022.907481

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Copyright © 2022 Soltan, Abdulsahib, Amer, Refaat, Bagalagel, Diri, Albogami, Fayad, Eid, Sharaf, Elhady, Darwish and Eldeen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Docked complex and interface binding interactions for the designed vaccine and the two investigated TLRs; (A) multiepitope vaccine/TLR-4 and (B) multiepitope vaccine/TLR-8 complexes. 3D cartoon representation of the docked vaccine (red) at the TLR binding site (green and blue for protomer A and B, respectively). The protruding loops into the TLR-8 binding site are colored magenta. The carboxy and amine terminals of the simulated epitopes are assigned with C and N-letters, respectively. Zoomed images illustrate the surface representation of multiepitope vaccine/TLR binding polar interactions showing the residue pairs as lines, colored depending on their location within the proteins, and numbered according to their respective residue sequence. The bonds of polar interactions are shown as black dashed lines.