Figure 1.

Schematic of types of heterogeneity among a population of CD8⁺ T cells responding to antigenic stimulation. Variation in (left) antigenic and/or microenvironmental signals is associated with (middle) different time delays before activation, gene expression patterns, proliferation profiles, and lymphoid tissue locations during the activation and expansion phases of the response. Many of these forms of heterogeneity are also associated with (right) subsequent differentiation fates. Created with Biorender.com.