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. 2022 Jul 15;13:801337. doi: 10.3389/fphar.2022.801337

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Copyright © 2022 Zhang, Zhang, Li, Huang, Jiang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metformin suppresses the LPS-induced downregulation of SIRT1 both in vivo and in vitro. (A) Effects of metformin on the expression level of SIRT1 and NF-κB signaling pathway in pulmonary tissues of mice that received LPS intratracheally. Indicative bands are shown on the top of the histogram. Data are presented as mean ± SEM (n = 7). (B) Effects of metformin on the expression level of SIRT1 and NF-κB signaling pathway in primarily cultured pulmonary ECs. Representative bands are shown. Data are presented as mean ± SEM (n = 4). (C) Effects of metformin on the expression level of p65 lysine 310 acetylation in LPS-challenged mouse lung tissues. Data are presented as mean ± SEM (n = 7). (D) Effects of metformin on the expression level of p65 lysine 310 acetylation in LPS-treated pulmonary ECs. Data are presented as mean ± SEM (n = 4). **p < 0.01 vs. Control group, #p <0.05, ##p < 0.01 vs. LPS group.