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. 2022 Jul 15;13:801337. doi: 10.3389/fphar.2022.801337

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Copyright © 2022 Zhang, Zhang, Li, Huang, Jiang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The inhibition of SIRT1 prevents metformin from ameliorating the morphological characteristics and endothelial hyperpermeability of ALI. NAM (60 mg/kg) was administered 1 h before metformin administration. (A) Representative HE staining of lung tissues. (B) Immunohistochemistry analysis of F4/80. (C) Immunohistochemistry of MPO. (D and E) Lung W/D and Evans-blue dye extravasation were determined as indexes of pulmonary edema. Original magnification, ×200. Scale bar, 50 μm. Data are presented as the mean ± SEM (n = 7). **p < 0.01 vs. Control group, ##p < 0.01 vs. LPS group. &&p < 0.01 vs. LPS + Met group.