Table 2.

Individual socio-demographic and clinical features of MND patients.

Subject	Mutation	Diagnosis	Sex (M/F)	Education (years)	Age at onset	Age at MRI (years)	Time onset to diagnosis (months)	ALSFSR-r [0-48]	MRC sum score	Disease progression rate	Bulb/limb onset	Site onset	Cognitive/ behavioral profile
1	TARDBP	ALS	M	8	70	71	7	44	NA	0.50	Limb	RUL	NA
2	TARDBP	ALS	F	8	61	63	13	44	NA	0.17	Limb	RLL	NA
3	TARDBP	ALS	F	11	50	56	35	36	103	0.18	Limb	LL	ALS-ci
4	TARDBP	PMA	M	8	62	62	3	33	79	2.50	limb	UL	PMA-ci
5	TARDBP	ALS	F	11	48	48	4	20	91	4.00	Bulb	–	ALS-ci
6	TARDBP	PMA	M	5	60	61	10	38	91	0.83	Limb	RUL	NA
7	TARDBP	ALS	M	NA	62	63	8	20	NA	2.80	Limb	LUL	NA
8	TARDBP	PLS	F	13	55	56	9	35	NA	1.08	Limb	RLL	Normal
9	TARDBP	ALS	F	16	67	67	4	40	95	1.60	Bulb	–	Normal
10	TARDBP	PMA	M	NA	65	67	11	25	50	1.43	Limb	RLL	PMA-ci
11	TARDBP	ALS	M	13	43	44	18	41	NA	0.36	Limb	RUL	NA
12	–	PMA	M	16	54	60	11	33	78	0.21	Limb	RUL	Normal
13	–	ALS	F	17	65	67	19	40	91	0.36	Limb	LL	Normal
14	–	ALS	F	13	57	58	8	33	91	1.36	Limb	NA	NA
15	–	PMA	M	13	59	60	6	32	109	2.00	Limb	LUL	NA
16	–	ALS	M	6	65	66	6	29	111	2.11	Bulb	–	Normal
17	–	PMA	M	13	41	65	156	25	66	0.08	Limb	RLL	NA
18	–	ALS	F	17	50	54	12	38	111	0.25	Bulb	–	Normal
19	–	ALS	F	11	40	45	25	23	60	0.38	Limb	LL	Normal
20	–	ALS	F	8	58	59	15	42	105	0.40	Limb	NA	NA
21	–	ALS	M	13	67	68	13	41	107	0.55	Limb	NA	NA
22	–	ALS	M	13	45	47	36	37	106	0.31	Limb	NA	NA

ALS, amyotrophic lateral sclerosis; -ci, cognitive impairment; F, female; LL, lower limbs; LUL, center upper limb; M, male; MRC, Medical Research Council scale; NA, not available; PMA, primary muscular atrophy; PLS, primary lateral sclerosis; RLL, right lower limb; RUL, right upper limb; UL, upper limbs. –, not applicable.