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. 2022 Jul 27;4(2):e000271. doi: 10.1136/bmjno-2022-000271

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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IgG reactivity measured as optical density in serum samples against (A) Epstein-Barr virus glycoprotein 350 (EBVgp350) and (B) measles virus nucleocapsid protein (MeV N_CORE). There were 170 patients with multiple sclerosis in the interferon beta (IFNβ) subgroup sampled at time point 1 (t1) and t2, 714 patients in the natalizumab (NAT) group, sampled at t3 and t4 and 144 blood donors. The boxplots demonstrate minimum, quartile 1, median, quartile 3 and maximum. The Mann-Whitney U test was used to compare the IgG levels in patients during IFNβ treatment at t1 and blood donors. The Wilcoxon signed-rank test was used to compare the anti-EBVgp350 and anti-MeV N_CORE IgG levels between the samples collected during IFNβ treatment at t1 and t2 and before (t3) and during (t4) NAT therapy. P values<0.008 (0.05/6 due to Bonferroni correction) were considered statistically significant.