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. 2022 Jul 27;4(2):e000271. doi: 10.1136/bmjno-2022-000271

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Tukey box plot illustrating changes in anti-Epstein-Barr virus glycoprotein 350 (EBVgp350) and anti-measles virus nucleocapsid (MeV N_CORE) IgG reactivity in serum samples from patients with multiple sclerosis. In all, 170 patients were sampled during interferon (IFNβ) treatment at time point 1 (t1) and t2 and 714 patients were sampled before (t3) and during natalizumab (NAT) treatment (t4). The relative levels of anti-EBVgp350 and anti-MeV N_CORE IgG were analysed by indirect ELISA and measured as optical density (OD). The OD value for the first sample taken at t1 or t3 was subtracted from the second value at t2 or t4, creating delta (∆) OD values.