Table 4.

Cox regression analyses of all-cause mortality according to TC and LDL-C levels in cases and controls

	Beta value	HR (95% CI) per 1 mmol/L	P value
	Case/control	Case/control	Case/control
TC, n=737/737	−0.36/−0.31	0.70 (0.62 to 0.79)/0.73 (0.60 to 0.89)	<0.001/0.002
TC*	−0.29/−0.20	0.75 (0.66 to 0.85)/0.86 (0.71 to 1.04)	<0.001/0.13
TC†	−0.19/−0.13	0.83 (0.73 to 0.95)/0.94 (0.76 to 1.16)	0.005/0.57
TC <median‡	−0.54/−0.60	0.58 (0.45 to 0.75)/0.55 (0.37 to 0.82)	<0.001/0.003
TC <median*	−0.50/−0.40	0.61 (0.47 to 0.79)/0.67 (0.45 to 1.01)	<0.001/0.054
TC <median†	−0.39/−0.32	0.68 (0.53 to 0.89)/0.72 (0.46 to 1.13)	0.004/0.15
TC ≥median‡	−0.22/0.39	0.80 (0.60 to 1.08)/1.48 (0.99 to 2.21)	0.14/0.058
TC ≥median*	−0.13/0.38	0.87 (0.65 to 1.17)/1.46 (0.94 to 2.28)	0.37/0.095
TC ≥median†	−0.11/0.44	0.90 (0.67 to 1.20)/1.56 (0.96 to 2.52)	0.47/0.073
LDL-C, n=703/703	−0.44/−0.33	0.64 (0.56 to 0.74)/0.74 (0.59 to 0.93)	<0.001/0.010
LDL-C*	−0.37/−0.21	0.69 (0.60 to 0.80)/0.87 (0.70 to 1.08)	<0.001/0.21
LDL-C†	−0.24/−0.07	0.79 (0.67 to 0.92)/0.96 (0.75 to 1.22)	0.003/0.71
LDL-C <median‡	−0.47/−0.48	0.64 (0.46 to 0.87)/0.62 (0.41 to 0.95)	0.002/0.027
LDL-C <median*	−0.45/−0.29	0.64 (0.47 to 0.86)/0.75 (0.49 to 1.16)	0.004/0.20
LDL-C <median†	−0.32/−0.22	0.73 (0.53 to 1.00)/0.79 (0.48 to 1.28)	0.052/0.34
LDL-C ≥median‡	−0.01/0.61	0.99 (0.75 to 1.30)/1.83 (1.14 to 2.95)	0.93/0.013
LDL-C ≥median*	0.08/0.57	1.09 (0.81 to 1.45)/1.77 (1.08 to 2.91)	0.58/0.024
LDL-C ≥median†	0.11/0.64	1.11 (0.83 to 1.49)/1.89 (1.09 to 3.28)	0.48/0.023

The median follow-up time for cases and controls taken together was 8.2 years.

*Adjusted for age and sex.

†Adjusted for age, sex, diabetes, hypertension and previously diagnosed angina pectoris.

‡Medians for TC cases, TC controls, LDL-C cases and LDL-C controls were 5.0, 5.6, 3.2 and 3.7 mmol/L, respectively.

LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol.