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. 2022 Jul 27;8(2):e002280. doi: 10.1136/rmdopen-2022-002280

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Changes from baseline in back pain and nocturnal back pain over time. Dashed line: all patients randomised to placebo in period 1 who received open-label upadacitinib starting from week 14. Back pain is based on the question, ‘What is the amount of back pain that you experienced at any time during the last week?’ and nocturnal back pain on the question, ‘What is the amount of back pain at night that you experienced during the last week?’ Both scored on a numeric rating scale of 0–10. AO, as observed; MMRM, mixed-effect model repeated measure; QD, once daily; W, week.