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. 2021 Dec 23;107(8):1746–1757. doi: 10.3324/haematol.2021.279410

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Copyright© 2022 Ferrata Storti Foundation

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Figure 4. — Cell cycle regulators are upregulated in CDK inhibitor-resistant T-cell acute lymphoblastic leukemia. (A) Schematic representation of the method of generating de novo CDK inhibitor (CDKi)‐resistant cells using palbociclib dose escalation. (B) Cell cycle analysis of 1 mM palbociclib (palbo) treated parental and palbociclib-resistant cells. (C) Western blotting of pRB and Cyclin D3 (CCND3) in parental and palbociclib-resistant cells. (D) Differential expression of cell cycle genes in treatment of parental and CDKi-resistant cells.