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Treatment schema of pretreatment versus concurrent regimens in vivo. Treatment schema depicting the timing of each drug (vincristine, dexamethasone or L-asparaginase and/or CDK inhibitor [CDKi]) vs. vehicle in the pretreatment and concurrent schema. Veh: vehicle; chemo: chemotherapy; hB-ALL: human B-cell acute lymphoblastic leukemia; palbo: palbociclib.
