TABLE 3.

Logistic regression analysis of the relationship between alkaline phosphatase (ALP) and globulin with hemorrhagic transformation (HT).

	Variables	OR	95% CI	P
Unadjusted	ALP	1.002	0.995–1.010	0.551
	Globulin	1.053	1.008–1.101	0.020
Model 1	ALP	1.003	0.996–1.010	0.446
	Globulin	1.058	1.011–1.107	0.014
Model 2	ALP	1.003	0.996–1.010	0.425
	Globulin	1.052	1.003–1.103	0.035
Model 3	ALP	1.003	0.996–1.011	0.378
	Globulin	1.055	1.006–1.106	0.026
Model 4	ALP	1.003	0.995–1.011	0.456
	Globulin	1.055	1.006–1.107	0.028

Model 1 was adjusted for age, sex; Model 2 was adjusted for Model 1 + vascular risk factors, including cigarette smoking, alcohol consumption, atrial fibrillation, coronary heart disease, hypertension, diabetes mellitus, dyslipidemia, and previous stroke; Model 3 was adjusted for Model 2 + history of previous medications, including antihypertensive therapy, hypoglycemic therapy, and antiplatelet therapy; Model 4 was adjusted for Model 3 + baseline NIHSS score, baseline SBP and DBP, baseline blood glucose, ONT, and TOAST.

HT, hemorrhagic transformation; OR, odds ratio; 95% CI, 95% confidence interval; ALP, alkaline phosphatase; SBP, systolic blood pressure; DBP, diastolic blood pressure; NIHSS, National Institutes of Health Stroke Scale; ONT, onset to needle time; TOAST, Trial of Org 10172 in acute stroke treatment.