TABLE 5.

Logistic regression analysis of the relationship between alkaline phosphatase (ALP) and globulin with poor outcome.

	Variables	OR	95% CI	P
Unadjusted	ALP	1.010	1.004–1.016	0.001
	Globulin	1.063	1.026–1.101	0.001
Model 1	ALP	1.010	1.003–1.016	0.003
	Globulin	1.055	1.018–1.094	0.003
Model 2	ALP	1.010	1.004–1.016	0.002
	Globulin	1.059	1.020–1.099	0.003
Model 3	ALP	1.011	1.005–1.018	0.001
	Globulin	1.056	1.017–1.096	0.004
Model 4	ALP	1.009	1.002–1.016	0.010
	Globulin	1.062	1.020–1.107	0.004

Model 1 was adjusted for age, sex; Model 2 was adjusted for Model 1 + vascular risk factors, including cigarette smoking, alcohol consumption, atrial fibrillation, coronary heart disease, hypertension, diabetes mellitus, dyslipidemia, and previous stroke; Model 3 was adjusted for Model 2 + history of previous medications, including antihypertensive therapy, hypoglycemic therapy, and antiplatelet therapy; Model 4 was adjusted for Model 3 + baseline NIHSS score, baseline SBP and DBP, baseline blood glucose, ONT, and TOAST.

OR, odds ratio; 95% CI, 95% confidence interval; ALP, alkaline phosphatase; SBP, systolic blood pressure; DBP, diastolic blood pressure; NIHSS, National Institutes of Health Stroke Scale; ONT, onset to needle time; TOAST, Trial of Org 10172 in acute stroke treatment.