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. Author manuscript; available in PMC: 2022 Jul 29.
Published in final edited form as: Pharm Stat. 2018 Nov 20;18(2):212–222. doi: 10.1002/pst.1916

Table 2:

The number of paired events ñ required of the trial under the Weibull frailty model for one-sided hypothesis with type I error of 5% and power of 80%. Based on 100,000 simulation runs, the empirical type I errors (α^) and empirical powers (EP) corresponding to the calculated number of paired events are also recorded in the table.

Number of paired events ñ (α^EP)
R Δ κ = 0.5 Δ κ = 1 Δ κ = 2
1.5 1.2247 769(.051/.80) 1.5 196(.053/.81) 2.25 53(.053/.83)
1.6 1.2649 574(.049/.80) 1.6 147(.048/.80) 2.56 41(.059/.85)
1.7 1.3038 451(.048/.80) 1.7 117(.041/.79) 2.89 33(.035/.79)
1.8 1.3416 369(.048/.80) 1.8 96 (.051/.81) 3.24 28(.036/.80)
1.9 1.3784 310(.048/.80) 1.9 81 (.045/.80) 3.61 24(.064/.87)
2.0 1.4142 267(.051/.81) 2.0 71 (.058/.83) 4.00 22(.051/.87)
2.1 1.4491 233(.049/.80) 2.1 62 (.057/.83) 4.41 20(.042/.85)
2.2 1.4832 207(.053/.81) 2.2 56 (.045/.81) 4.84 18(.030/.82)
2.3 1.5166 186(.047/.80) 2.3 51 (.049/.82) 5.29 17(.049/.88)
2.4 1.5492 169(.046/.79) 2.4 46 (.054/.83) 5.76 16(.077/.92)
2.5 1.5811 155(.054/.82) 2.5 43 (.065/.86) 6.25 15(.036/.86)