Table 3.
Different grades of toxicities in first and second cycles (N=52) caused by 5-FU-based chemotherapy in the patients with different genotypes of MTHFR polymorphism.
| Toxicity | Gene | Genotype | N | First cycle | Second cycle | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Grade 1-4an (%) | P | Grade 3-4bn (%) | P | Grade 1-4an (%) | P | Grade 3-4bn (%) | P | ||||
| Anemia | MTHFR 677G>A | GG | 35 | 19 (54.3) | 0.223 | 0 (0.0) | ND | 14 (40.0) | 0.333 | 0 (0.0) | ND |
| GA + AA | 17 | 12 (70.6) | 0 (0.0) | 9 (52.9) | 0 (0.0) | ||||||
| MTHFR 1298A>C | AA | 31 | 17 (54.8) | 0.343 | 0 (0.0) | ND | 13 (41.9) | 0.650 | 0 (0.0) | ND | |
| AC + CC | 21 | 14 (66.7) | 0 (0.0) | 10 (47.6) | 0 (0.0) | ||||||
| Leucopenia | MTHFR 677G>A | GG | 35 | 8 (22.9) | 0.544 | 0 (0.0) | 0.036* | 11 (31.3) | 0.224 | 0 (0.0) | ND |
| GA + AA | 17 | 5 (29.4) | 2 (11.8) | 8 (47.1) | 0 (0.0) | ||||||
| MTHFR 1298A>C | AA | 31 | 7 (22.6) | 0.579 | 2 (6.5) | 0.568 | 12 (38.7) | 0.660 | 0 (0.0) | ND | |
| AC + CC | 21 | 6 (28.6) | 0 (0.0) | 7 (33.3) | 0 (0.0) | ||||||
| Neutropenia | MTHFR 677G>A | GG | 35 | 11 (31.4) | 0.768 | 5 (14.3) | 0.712 | 10 (28.6) | 0.945 | 1 (2.9) | 0.049* |
| GA + AA | 17 | 4 (23.5) | 3 (17.6) | 5 (29.4) | 3 (17.6) | ||||||
| MTHFR 1298A>C | AA | 31 | 9 (29.0) | 0.968 | 4 (12.9) | 0.488 | 9 (29.0) | 0.968 | 2 (6.5) | 0.640 | |
| AC + CC | 21 | 6 (28.6) | 4 (19.0) | 6 (28.6) | 2 (9.5) | ||||||
| Thrombocytopenia | MTHFR 677G>A | GG | 35 | 0 (0.0) | ND | 0 (0.0) | ND | 0 (0.0) | <0.001* | 0 (0.0) | 0.195 |
| GA + AA | 17 | 0 (0.0) | 0 (0.0) | 5 (29.4) | 1 (5.9) | ||||||
| MTHFR 1298A>C | AA | 31 | 0 (0.0) | ND | 0 (0.0) | ND | 5 (16.1) | 0.059 | 1 (3.2) | 0.405 | |
| AC + CC | 21 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 0 (0.0) | ||||||
ND = Not determined; * P value < 0.05 was considered statistically significant. aGrade 1–4 was considered as toxicity. bGrade 3–4 was considered as severe toxicity.