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Response rate of Thai colorectal cancer patients (N=52) in 5-FU based therapy.
| Gene | Genotype | N | Responders (CR + PR) (N=7) | Non-responders (SD + PD) (N=45) | P value |
|---|---|---|---|---|---|
| MTHFR 677G>A | GG | 35 | 5 (14.3) | 30 (85.7) | 1.000 |
| GA + AA | 17 | 2 (11.8) | 15 (88.2) | ||
| MTHFR 1298A>C | AA | 31 | 5 (16.1) | 26 (83.9) | 0.721 |
| AC + CC | 21 | 2 (9.5) | 19 (90.5) |
p value < 0.05 was considered as severe toxicity.
