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. 2022 Jul 15;13:899271. doi: 10.3389/fendo.2022.899271

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Copyright © 2022 Chu, Chan, Yip, Chu, Wang and Pang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical features of anterior inflammation in the rat eyes. (A) Schematic diagram of the experimental procedures. (B) Control rats (saline+water ingestion) showed no inflammatory manifestation by slit-lamp examination. Iris of LPS treated EIU rats 24 hours after LPS injection (LPS+water) showed hyperemia (red arrow) and edema (green arrow). EIU rats treated by GTE two hours after LPS injection (LPS+GTE) showed suppression of inflammatory responses. (C) Clinical manifestation score of ocular inflammation in normal control rats (saline+water), EIU (LPS+water) rats, and EIU rats treated by GTE (LPS+GTE). n=6 in each group. Error bar indicates standard deviation. —: comparison between two groups. ** - p < 0.05 comparing with different treatment groups by Mann–Whitney U test. (D) Inter-group comparisons of a-wave and b-wave of scotopic ERG amplitudes. Rats were tested 24 hours after LPS injection. The asterisk marked the statistical significance of the comparison between the three groups. Data are also presented as mean ± SD and analyzed by ANOVA test (*P < 0.05, n = 3; both eyes from each rat).