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. 2022 Jul 15;13:899271. doi: 10.3389/fendo.2022.899271

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Copyright © 2022 Chu, Chan, Yip, Chu, Wang and Pang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmaps of metabolites showed patterns of differential metabolite profiles between different treatment groups in retina. (A) Between controls and EIU as induced by LPS in the retina; (B) Between EIU induced by LPS and after GTE treatment in the retina. Principal component analysis (PCA) showed (C) comparison of controls and EIU induced by LPS samples in the retina, and (D) comparison of EIU induced by LPS induction and after GTE treatment samples in the retina. Metabolites and their associated biological activities were shown in (E) the iris ciliary body of the EIU rats after GTE treatment, (E) the retina of EIU induced by LPS, and (F) the retina of EIU after and GTE treatment.