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. 2022 Jul 18;119(30):e2201067119. doi: 10.1073/pnas.2201067119

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Copyright © 2022 the Author(s). Published by PNAS

This article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 2. — Potency of [Gln^6,14]CNP-38 in cell-based and growth assays. (A) Stimulation of 3T3 cell guanylate cyclase by [Gln^6,14]CNP-38 () and vosoritide (•). (B) Effects of [Gln^6,14]CNP-38 and vosoritide on TBL (nasoanal + tail length) growth of 3-wk-old FVB/nJ male mice. Groups of 3-wk-old wild-type mice (n = 6) were given daily subcutaneous administrations of 70 nmol/kg CNP variants or vehicle for 5 wk. cGMP, cyclic guanosine monophosphate. ns, not significant.

Inline graphic — Potency of [Gln^6,14]CNP-38 in cell-based and growth assays. (A) Stimulation of 3T3 cell guanylate cyclase by [Gln^6,14]CNP-38 () and vosoritide (•). (B) Effects of [Gln^6,14]CNP-38 and vosoritide on TBL (nasoanal + tail length) growth of 3-wk-old FVB/nJ male mice. Groups of 3-wk-old wild-type mice (n = 6) were given daily subcutaneous administrations of 70 nmol/kg CNP variants or vehicle for 5 wk. cGMP, cyclic guanosine monophosphate. ns, not significant.