TABLE 2.

Role and mechanism of circ-ITCH in non-tumor diseases and physiology.

Disease/Physiology	miRNA	Target Proteins/Signaling Pathway	Effect	Ref
Osteoporosis	miR-214	YAP1	Promoting osteogenic differentiation	Zhong et al. (2021)
IDD	miR-17-5p	SOX4; Wnt/β-catenin (activating)	Promoting ECM degradation and NP cell apoptosis	Zhang et al. (2021)
Myocardial I/R injury	miR-17-5p	Wnt/β-catenin (inactivating)	Enhancing cardiomyocyte viability and ATP concentration; Inhibiting cardiomyocyte apoptosis	Zhang et al. (2020)
DOXIC	miR-330-5p	SIRT6, Survivin, SERCA2a	Alleviating cell/mitochondrial oxidative stress and DNA damage	Han et al. (2020)
DR	--	MMP-2, MMP-9, TNF-α	Preventing neovascularization and inflammation to delay DR progression	Zhou et al. (2021a)
DN	miR-33a-5p	SIRT6	Ameliorating renal inflammation and fibrosis	Liu et al. (2021)
HSCR	miR-146b-5p	RET; MAPK	Promoting cell proliferation and migration to delay HSCR progression	Xia et al. (2022)
PDLSC	--	MAPK	Promoting osteogenic differentiation	Gu et al. (2017)