. Author manuscript; available in PMC: 2022 Jul 29.

Published in final edited form as: J Nurse Pract. 2020 Jul 31;16(9):673–678. doi: 10.1016/j.nurpra.2020.06.027

Table 6.

Recommended Treatment Regimens for Latent Tuberculosis Infection in Children^20–24a

Regimen (mo)	Dose	Interval	Total Doses	Adverse Effects
3INH/RPT^b	INH, age 2–11 years: 25 mg/kg INH, age ≥ 12 years: 15 mg/kg (max: 900 mg for both) RPT, 10–14 kg: 300 mg 14.1–25 kg: 450 mg 25.1–32 kg: 600 mg 32.1–50 kg: 750 mg > 50 kg: 900 mg	Weekly	12	Flu-like symptoms, nausea, GI upset, rash, muscle or bone pain, itching, red eyes, discoloration of secretions, decreased effectiveness of hormonal contraception, hepatic enzyme elevation, hepatitis
4RIF	15–20 mg/kg per day (max: 600 mg)	Daily	120	Anorexia, nausea, GI upset, rash, fatigue discoloration of secretions, decreased effectiveness of hormonal contraceptive
3INH/RIF	INH: 10–20 mg/kg (max: 300 mg) RIF: 15–20 mg/kg (max: 600 mg)	Daily	90	Rash, nausea, epigastric pain, photosensitivity reaction, hepatic enzyme elevation, discoloration of secretions, decreased effectiveness of hormonal contraceptive
6INH	10–20 mg/kg per day (max: 300 mg)^d 20–40 mg/kg (max: 300 mg)^d	Daily Twice weekly	180 52	GI upset, rash, peripheral neuropathy, hepatic enzyme elevation, hepatitis
9INH^c	10–20 mg/kg per day (max: 300 mg)^d 20–40 mg/kg (max: 300 mg)^d	Daily Twice weekly	270 76

GI = gastrointestinal; INH = isoniazid (isonicotinic acid hydrazide); RIF = rifampin; RPT = rifapentine.

Adapted from Centers for Disease Control and Prevention: www.cdc.gov/tb/topic/treatment/ltbi.htm

Only for children ≥ 2 years of age due to lack of safety and pharmacokinetic data for younger children. Not recommended for adolescents who are pregnant or might become pregnant within the 12-week regimen.

Preferred treatment for children being treated for HIV with certain protease inhibitors or adolescents who are pregnant or who might become pregnant (supplement with pyridoxine/vitamin B₆ for these groups and others at risk of malnutrition to prevent peripheral neuropathy).

The American Academy of Pediatrics recommends an INH dosage of 10–15 mg/kg for the daily regimen and 20–30 mg/kg for the twice-weekly regimen.