Fig. 12.

Neuroendocrine differentiation in prostate cancer. 65 year old male with metastatic prostate adenocarcinoma on hormonal therapy. Serial CT scans at one month (A, C) and four months (B, D) after initiation of treatment. There is progressive increase in size of a urinary bladder mass at the right ureterovesical junction (arrows in A and B), an unusual site of metastasis for prostate cancer. This was noted despite response at typical sites of metastatic disease including retroperitoneal lymph nodes (notched arrows in C and D) and bones. Biopsy of the bladder mass showed focal neuroendocrine differentiation of prostate cancer.