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. 2022 Jul 15;13:899971. doi: 10.3389/fimmu.2022.899971

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Copyright © 2022 Cheng, Wang, Hu, Sun, Zhao, Zhang, Wang, Wang and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The microenvironment in patients with immune checkpoint inhibitor-related pneumonitis. (A–C) Imaging mass cytometry (IMC) imaging of formalin-fixed paraffin-embedded lung tissue specimen. (D) Statistical t-distributed stochastic neighbor embedding (tSNE) plots were generated to divide the cell populations into 11 clusters according to phenotypic similarity. (E) Heat map analysis of the mean expression of analyzed markers from 11 identified clusters. The expression levels are indicated by heat colors. (F) Neighborhood analysis revealed cell-to-cell interactions between different clusters.