TABLE 1.

Examples of fungal expression platforms for the production of natural products and the characterization of biosynthetic gene clusters.

Species	Platform strains	Genotype	Examples of NP	References
Aspergillus nidulans	A1145	pyrG89; pyroA4; nkuA::argB; riboB2	Flavunoidine	Yee et al. (2020)
	A1145 ΔSTΔEM	A1145 Δstc-BGC, Δeas-BGC	Myceliothermophin	Li et al. (2016)
	LO4389	A1145 ΔstcA-stcW	Zaragozic acid A precursor	Liu et al. (2017)
	LO8030	A1145 Δstc-BGC, Δeas-BGC, Δafo-BGC, Δmdp-BGC, Δtdi-BGC, Δaus-BGC, Δors-BGC, Δapt-BGC	Trihazone A-F	Zhu et al. (2021)
	YM87 & YM137	LO4389 AN1029::PalcA-AN1029; AN1036-AN1032 (31)::AfriboB	Asperfuranone	Chiang et al. (2013)
		A1145 Δstc-BGC, Δeas-BGC	Aspercryptin	Chiang et al. (2016)
		A1145 ΔstcA-stcW	Felinone A	Oakley et al. (2017)
			Citreoviridin	Chiang et al. (2020)
			Mutilin	Chiang et al. (2020)
			Pleuromutilin	Chiang et al. (2020)
Aspergillus oryzae	NSAR1	niaD−, sC−, ΔargB, adeA-	Strobilurin	Nofiani et al. (2018)
	NSARΔK	NSAR1 ΔkojA	Paxilline	Tagami et al. (2013)
	NSPlD1	niaD−, sC−, pyrG−, ligD-	Erinacine Q	Liu et al. (2019a)
			Pretenellin A	Dao et al. (2021)
			Kojic acid	Yamada et al. (2014)
Aspergillus niger	AB1.13	pyrG1, prtT-	Enniatin	Richter et al. (2014)
			Beauvaricin	Boecker et al. (2018)
			Bassianolide	Boecker et al. (2018)
Aspergillus terreus	ΔakuB	SBUG844 ΔakuB::hphR	Isoflavipucine	Gressler et al. (2011)
	HZ03	Δku80::ptrA, ΔpyrG	Dihydroisoflavipucine	Gressler et al. (2011)
			Monacolin J	Huang et al. (2019)
Penicillium rubens	4xKO	∆hdfA, ∆pen-BGC, ∆chy-BGC, ∆roq-BGC: amdS, ∆hcpA: ble	Penicillin	Pohl et al. (2020)
			Decumbenone A-C	Pohl et al. (2020)
Trichoderma reseei	ΔpyrG	QM6a Δtmus53, ΔpyrG	Sorbicillinoids	Derntl et al. (2017)