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. 2022 Jul 28;140(4):303–308. doi: 10.1182/blood.2021014663

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Figure 1. — Mechanism of action of PBD-ADCs (loncastuximab tesirine [Lonca]). (1) Lonca binds to CD19 on the tumor cell surface; (2) following internalization of Lonca, the protease-sensitive linker is cleaved and cytotoxic PBD dimers are released inside the cell; (3) the free PBD dimers bind in the minor groove of the cell DNA and form potent cytotoxic DNA cross-links in a sequence- selective fashion; (4) the cross-links result in a stalled DNA replication fork, blocking cell division; and (5) the cancer cell undergoes apoptosis.