Skip to main content
. 2022 May 20;122(14):12308–12369. doi: 10.1021/acs.chemrev.1c00862

Table 3. Scope of the Cyclization of o-Alkynylbenzonitriles (X and Y Can Be CH or N) and Amides Using 29a (See Scheme 12).

3.1.1.4.

Entry Compound R1 R2 Yield of 73al (%) Yield of 74al (%)
1 72a Ph H 48 15
2 72b p-MeO-C6H4 H 31 6
3 72c p-F-C6H4 H 40 5
4 72d o-CH3-C6H4 H 0 0
5 72e o-Cl-C6H4 H 0 5
6 72f 3-Pyridyl H 30 12
7 72g 3-Thiophene H 49 14
8 72h Cyclohexyl H 43 19
9 72i Ph 3-F 42 ∼5
10 72j Ph 5-CF3 37 11
11 72k Ph 5-MeO 16 <5
12 72l Ph 4-Me 40 16