Table 3. Scope of the Cyclization of o-Alkynylbenzonitriles (X and Y Can Be CH or N) and Amides Using 29a (See Scheme 12).
| Entry | Compound | R1 | R2 | Yield of 73a–l (%) | Yield of 74a–l (%) |
|---|---|---|---|---|---|
| 1 | 72a | Ph | H | 48 | 15 |
| 2 | 72b | p-MeO-C6H4 | H | 31 | 6 |
| 3 | 72c | p-F-C6H4 | H | 40 | 5 |
| 4 | 72d | o-CH3-C6H4 | H | 0 | 0 |
| 5 | 72e | o-Cl-C6H4 | H | 0 | 5 |
| 6 | 72f | 3-Pyridyl | H | 30 | 12 |
| 7 | 72g | 3-Thiophene | H | 49 | 14 |
| 8 | 72h | Cyclohexyl | H | 43 | 19 |
| 9 | 72i | Ph | 3-F | 42 | ∼5 |
| 10 | 72j | Ph | 5-CF3 | 37 | 11 |
| 11 | 72k | Ph | 5-MeO | 16 | <5 |
| 12 | 72l | Ph | 4-Me | 40 | 16 |
