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. Author manuscript; available in PMC: 2023 Mar 30.
Published in final edited form as: Stat Med. 2021 Nov 25;41(7):1205–1224. doi: 10.1002/sim.9265

Table 5:

Selection percentage and the average number of patients treated at each dose for the two subgroups under the BIPSE design with an alternative data-generating process.

Z=0
Z=1
Scenario 1
Sel % 0.036 0.680 0.172 0.002 0.004 0.362 0.627 0.006 0.000 0.000
# of patients 7.5 7.4 6.4 3.7 1.8 10.0 9.0 5.3 1.9 0.5
Scenario 2
Sel % 0.000 0.108 0.692 0.138 0.032 0.000 0.132 0.716 0.126 0.022
# of patients 4.5 7.3 7.5 6.0 3.7 6.1 7.8 7.2 5.5 3.2
Scenario 3
Sel % 0.002 0.002 0.004 0.012 0.978 0.000 0.000 0.000 0.018 0.980
# of patients 3.5 6.4 6.8 6.8 6.2 4.9 6.0 6.6 6.6 5.8
Scenario 4
Sel % 0.000 0.066 0.584 0.282 0.066 0.028 0.668 0.292 0.010 0.000
# of patients 6.0 6.8 6.8 5.8 4.2 6.7 7.1 6.8 5.7 4.1
Scenario 5
Sel % 0.000 0.002 0.038 0.248 0.712 0.002 0.038 0.600 0.204 0.156
# of patients 4.8 6.3 7.0 6.7 5.1 5.8 7.4 7.1 5.7 4.1
Scenario 6
Sel % 0.066 0.458 0.314 0.078 0.068 0.132 0.648 0.196 0.020 0.000
# of patients 7.0 8.0 7.1 4.6 2.7 10.6 11.2 5.4 2.1 0.6
Scenario 7
Sel % 0.000 0.006 0.514 0.386 0.094 0.000 0.122 0.726 0.124 0.028
# of patients 5.5 6.8 6.9 6.1 4.4 6.0 6.9 6.9 6.1 4.3
Scenario 8
Sel % 0.000 0.002 0.014 0.238 0.744 0.000 0.000 0.048 0.304 0.646
# of patients 4.8 6.2 6.8 6.7 5.5 4.9 6.4 7.0 6.4 5.1
Scenario 9
Sel % 0.000 0.000 0.196 0.380 0.422 0.008 0.456 0.412 0.032 0.090
# of patients 5.2 6.9 6.9 6.2 4.8 6.6 7.4 6.8 5.2 3.9
Scenario 10
Sel % 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000 0.000
# of patients 1.7 0.8 0.1 0.0 0.0 2.1 1.5 0.3 0.0 0.0